[The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases].

PURPOSE: To discuss the diagnosis and treatment of necrosis of jaws caused by leakage of arsenite trioxide, and to emphasize the consequences of its use.

METHODS

Ten cases of arsenical necrosis of the jaws from Jan, 2009 to Jun, 2014 treated in our department were collected and analyzed, with emphasis on the key points of diagnosis and treatment.

RESULTS

Diagnosis was based on medical history, clinical examinations, X-ray findings, and preoperative or intraoperative cone-beam CT (CBCT) scans. Nine patients were cured with primary operation, one patient was cured by secondary extended surgery.

CONCLUSIONS

Because of the high toxicity, there is no justification for the use of arsenite trioxide in clinic.