Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis.
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Ferraz-Amaro Iván, Rueda-Gotor Javier, Genre Fernanda, Corrales Alfonso, Blanco Ricardo, Portilla Virginia, González Mazón Iñigo, Llorca Javier, Expósito Rosa, Vicente Esther F, Quevedo-Abeledo Juan Carlos, Rodríguez-Lozano Carlos, Ortega-Castro Rafaela, Ladehesa-Pineda María Lourdes, Fernández-Carballido Cristina, Martínez-Vidal M Paz, Castro-Corredor David, Anino-Fernández Joaquín, García Vivar María Luz, Galíndez-Agirregoikoa Eva, Peiteado Diana, Plasencia-Rodríguez Chamaida, Montes Perez Esther, Fernández Díaz Carlos, Castañeda Santos, González-Gay Miguel Ángel
Аннотация
METHODS: A cross-sectional study that encompassed 804 patients with axSpA was conducted. Patients were assessed for the presence of five traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking status), and disease activity measurements. A multivariable regression analysis was performed to evaluate whether the number of classic CV risk factors was independently associated with specific features of the disease, to include disease activity.
RESULTS: A multivariable analysis showed that Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP) activity score was significantly higher in patients with 1 [beta coefficient 0.3 (95% confidence interval (CI) 0.1-0.5), p = 0.001] and ⩾2 [beta coefficient 0.5 (95% CI 0.3-0.7), p = 0.000] CV risk factors compared with those without CV risk factors. Similarly, patients with 1 [OR 2.00 (95%CI 0.99-4.02), p = 0.053] and ⩾2 [OR 3.39 (95%CI 1.82-6.31), p = 0.000] CV risk factors had a higher odds ratio for the presence of high disease activity compared with the zero CV category. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) activity score was significantly associated with the number of CV risk factors, being higher in patients with more CV risk factors. These relationships showed a CV risk factor-dependent effect being beta coefficients and ORs higher for the effect of ⩾2 over 1 CV risk factor.
CONCLUSION: Among patients with axSpA, as the number of traditional CV risk factors increased, disease activity similarly increases in an independent manner.