Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2025
A cluster of 11 cases of Listeria monocytogenes bacteremia in Kyoto, Japan.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tsuboi Hajime, Matsubara Shin, Kawahara Yoshiyuki, Konaka Kenji, Tamai Kaori, Yokoi Daisuke, Tanabe Yoshihiro, Fujita Naohisa, Shikata Satoru
Аннотация
BACKGROUND: Listeria monocytogenes infection, known as listeriosis, is relatively uncommon. However, in elderly or immunocompromised patients, it can lead to severe manifestations such as meningitis and bacteremia, making it a clinically important disease. The primary route of transmission is through ingestion of contaminated food, and since a wide range of food items may be involved, close collaboration with public health authorities is essential for effective source identification.
CASE REPORT: We encountered 11 cases of Listeria monocytogenes bacteremia within a limited region over the course of one month. Whole-genome sequencing revealed that the isolates were highly genetically related. Notably, the patients resided in different municipalities, suggesting exposure to a widely distributed food source. However, under the current Japanese legal framework, bacteremia is not a notifiable condition, which hindered timely identification of the infection source.
CONCLUSION: This case series underscores challenges in both clinical practice and the public health system in Japan, highlighting how such rare, genetically related clusters of bacteremia, occurring within a short period and across multiple municipalities, can easily be overlooked under the current surveillance framework.
CASE REPORT: We encountered 11 cases of Listeria monocytogenes bacteremia within a limited region over the course of one month. Whole-genome sequencing revealed that the isolates were highly genetically related. Notably, the patients resided in different municipalities, suggesting exposure to a widely distributed food source. However, under the current Japanese legal framework, bacteremia is not a notifiable condition, which hindered timely identification of the infection source.
CONCLUSION: This case series underscores challenges in both clinical practice and the public health system in Japan, highlighting how such rare, genetically related clusters of bacteremia, occurring within a short period and across multiple municipalities, can easily be overlooked under the current surveillance framework.