Science (New York, N.Y.) · 2021
Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hu Zehan, Zhang Chenlu, Sifuentes-Dominguez Luis, Zarek Christina M, Propheter Daniel C, Kuang Zheng, Wang Yuhao, Pendse Mihir, Ruhn Kelly A, Hassell Brian, Behrendt Cassie L, Zhang Bo, Raj Prithvi, Harris-Tryon Tamia A, Reese Tiffany A, Hooper Lora V
Аннотация
A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this study, SPRR2A was expressed in Paneth cells and goblet cells and selectively killed Gram-positive bacteria by disrupting their membranes. SPRR2A shaped intestinal microbiota composition, restricted bacterial association with the intestinal surface, and protected against Listeria monocytogenes infection. SPRR2A differed from other intestinal AMPs in that it was induced by type 2 cytokines produced during helminth infection. Moreover, SPRR2A protected against helminth-induced bacterial invasion of intestinal tissue. Thus, SPRR2A is a distinctive AMP triggered by type 2 immunity that protects the intestinal barrier during helminth infection.
Предметные рубрики MeSH
AnimalsBacterial LoadCell MembraneCell Membrane PermeabilityCornified Envelope Proline-Rich ProteinsCytokinesDisease SusceptibilityGastrointestinal MicrobiomeGoblet CellsGram-Positive BacteriaHumansImmunity, InnateIntestinal MucosaIntestinesListeria monocytogenesListeriosisMiceMicrobial ViabilityNematospiroides dubiusPaneth CellsPore Forming Cytotoxic ProteinsStrongylida Infections