Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.
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Bursill David, Taylor William J, Terkeltaub Robert, Abhishek Abhishek, So Alexander K, Vargas-Santos Ana Beatriz, Gaffo Angelo Lino, Rosenthal Ann, Tausche Anne-Kathrin, Reginato Anthony, Manger Bernhard, Sciré Carlo, Pineda Carlos, van Durme Caroline, Lin Ching-Tsai, Yin Congcong, Albert Daniel Arthur, Biernat-Kaluza Edyta, Roddy Edward, Pascual Eliseo, Becce Fabio, Perez-Ruiz Fernando, Sivera Francisca, Lioté Frédéric, Schett Georg, Nuki George, Filippou Georgios, McCarthy Geraldine, da Rocha Castelar Pinheiro Geraldo, Ea Hang-Korng, Tupinambá Helena De Almeida, Yamanaka Hisashi, Choi Hyon K, Mackay James, ODell James R, Vázquez Mellado Janitzia, Singh Jasvinder A, Fitzgerald John D, Jacobsson Lennart T H, Joosten Leo, Harrold Leslie R, Stamp Lisa, Andrés Mariano, Gutierrez Marwin, Kuwabara Masanari, Dehlin Mats, Janssen Matthijs, Doherty Michael, Hershfield Michael S, Pillinger Michael, Edwards N Lawrence, Schlesinger Naomi, Kumar Nitin, Slot Ole, Ottaviani Sebastien, Richette Pascal, MacMullan Paul A, Chapman Peter T, Lipsky Peter E, Robinson Philip, Khanna Puja P, Gancheva Rada N, Grainger Rebecca, Johnson Richard J, Te Kampe Ritch, Keenan Robert T, Tedeschi Sara K, Kim Seoyoung, Choi Sung Jae, Fields Theodore R, Bardin Thomas, Uhlig Till, Jansen Tim, Merriman Tony, Pascart Tristan, Neogi Tuhina, Klück Viola, Louthrenoo Worawit, Dalbeth Nicola
Аннотация
METHODS: A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions.
RESULTS: The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus).
CONCLUSION: Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.