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Войти в исследования International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Screening for tuberculosis in prisons: efficacy of a breath-based diagnostic approach in a high prevalence setting.
СтатьяНазвание и аннотация: Перевод в очереди
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Paciello Luis Gómez, Jara Leonardo, Salina Marlene, Candia Lidia, Zeballos Lucas, Palacios Diego, Molinas Gladys, Benitez Belén, Gill Larissa, Martinez Marilia, Bordon Maria, Prieto Adrian, Berton Sofia, Battaglia Arturo, Meza Cynthia, Aguirre Sarita, Piñanez Claudia, Gonzalez Felipe, Ortellado Geronimo, Muñoz Pilar, Tortola Maria Teresa, Koedoot Nelleke, Novais Maria Joao, Neves Joao, Vieira Mariana, Silva Claudio, Torres Dulce, Bles Pauli, Aguiar Ana, Duarte Raquel, Sanchez-Montalvá Adrian, Espinosa-Pereiro Juan, Magis-Escurra Cecile
Аннотация
OBJECTIVES: Tuberculosis (TB) remains a major health threat in prisons, where overcrowding and limited access to care facilitate transmission. We evaluated the diagnostic accuracy and feasibility of the AeoNose for TB screening in Paraguayan prisons.
METHODS: In this cross-sectional diagnostic study, people deprived of liberty and prison staff underwent symptom screening, chest X-ray with CAD4TB (v6), and AeoNose breath sampling. Individuals with presumptive TB underwent GeneXpert and mycobacterial culture. Breath signals were analyzed using a convolutional neural network. Two subsets were evaluated: all participants with valid samples and the same population excluding prior TB. Five-fold cross-validation was applied.
RESULTS: Of 3752 individuals screened, 2993 had valid samples. TB prevalence was 6.7%. In subset 1 (188 TB cases) and subset 2 (142 TB cases), mean AUC was 0.634 (SD 0.040) and 0.624 (0.054). Sensitivity and specificity were 0.670 (95% CI: 0.592-0.737) and 0.537 (0.518-0.555), and 0.711 (0.630-0.793) and 0.505 (0.491-0.519).
CONCLUSION: Under real-world prison conditions, AeoNose did not meet WHO criteria for a TB triage test. However, large-scale breath-based screening using portable devices was feasible, supporting further development of non-invasive screening approaches.
METHODS: In this cross-sectional diagnostic study, people deprived of liberty and prison staff underwent symptom screening, chest X-ray with CAD4TB (v6), and AeoNose breath sampling. Individuals with presumptive TB underwent GeneXpert and mycobacterial culture. Breath signals were analyzed using a convolutional neural network. Two subsets were evaluated: all participants with valid samples and the same population excluding prior TB. Five-fold cross-validation was applied.
RESULTS: Of 3752 individuals screened, 2993 had valid samples. TB prevalence was 6.7%. In subset 1 (188 TB cases) and subset 2 (142 TB cases), mean AUC was 0.634 (SD 0.040) and 0.624 (0.054). Sensitivity and specificity were 0.670 (95% CI: 0.592-0.737) and 0.537 (0.518-0.555), and 0.711 (0.630-0.793) and 0.505 (0.491-0.519).
CONCLUSION: Under real-world prison conditions, AeoNose did not meet WHO criteria for a TB triage test. However, large-scale breath-based screening using portable devices was feasible, supporting further development of non-invasive screening approaches.