Modulating bone remodeling through magnetic field: Approach targeting metabolic dysregulation in diabetic osteoporosis.

Diabetes mellitus, a chronic metabolic disorder associated with high risk of cardiovascular disease, kidney disease, neuropathy and bone disorder, has emerged as a globally epidemic public health issue. Osteoporosis, the most common bone disease in middle-aged and elderly populations, demonstrates a particularly high prevalence in individuals with diabetes mellitus. This correlation underscores the urgent need to develop innovative strategies to improve the quality of life for patients with diabetic osteoporosis. Magnetic field-based physical therapy, a non-invasive therapeutic modality, presents distinct advantages over conventional treatments. Recent advances in biomagnetic research have unveiled novel biological and therapeutic effects of magnetic fields, with accumulating evidence supporting their potential clinical applications in bone-related disorders. This review critically examines the mechanistic links between diabetes mellitus and the deterioration of bone health, the therapeutic effects of both dynamic and static magnetic fields on diabetes-associated complications, with a specific focus on skeletal outcomes, and the prospective applications of magnetic fields intervention for maintaining bone health in diabetes mellitus. Ultimately, this review aims to propose novel therapeutic strategies for managing osteoporosis in diabetes mellitus through magnetic approaches.