Frontiers in musculoskeletal disorders · 2024
Elastic modulus of cadaveric acetabular labrum correlates with ultrashort echo time (UTE) apparent spin-spin (T2*) and spin-lattice (T1) relaxation times.
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Moazamian Dina, Hananouchi Takehito, Mohammadi Hamid Reza Shaterian, Hajian Seyed Alireza Tayarani, Dorthe Erik W, D'Lima Darryl, Ma Yajun, Jerban Saeed
Аннотация
INTRODUCTION: The acetabulum labrum plays a critical role in hip function. Medical imaging techniques for detecting labral degeneration may help improve our knowledge of its role in hip osteoarthritis (OA). This study aimed to explore the correlation between the mechanical properties of the acetabulum labrum and ultrashort echo time (UTE) MRI properties.
MATERIAL AND METHOD: Acetabular labrum specimens were dissected from 12 fresh-frozen human cadaveric hip joints (64.6±11.6 years old at the time of death, 7 female). UTE Cones sequences were used to measure apparent spin-spin (T2*) and spin-lattice (T1) relaxation times using a knee coil at 3T in a clinical MR scanner. The stiffness and the elastic modulus (E) of the specimens were measured before MRI scans using uniaxial tensile tests. Spearman's rank correlation coefficients of UTE-T2* and -T1 with their mechanical properties of them were calculated.
RESULTS: The human labrum specimen elastic modulus showed a significant inverse correlation with UTE-T2* (R=-0.67, P<0.05) and with UTE-T1 (R=-0.56, P=0.05). The stiffness of the specimens showed significant inverse correlations with UTE-T2* (R=-0.53, P=0.05) and UTE-T1 (R=-0.63, P=0.02).
CONCLUSION: This study highlighted the potential of UTE-MRI techniques for the mechanical assessment of the acetabular labrum. UTE-MRI may improve labrum degeneration detection and monitoring, which requires further investigations.
MATERIAL AND METHOD: Acetabular labrum specimens were dissected from 12 fresh-frozen human cadaveric hip joints (64.6±11.6 years old at the time of death, 7 female). UTE Cones sequences were used to measure apparent spin-spin (T2*) and spin-lattice (T1) relaxation times using a knee coil at 3T in a clinical MR scanner. The stiffness and the elastic modulus (E) of the specimens were measured before MRI scans using uniaxial tensile tests. Spearman's rank correlation coefficients of UTE-T2* and -T1 with their mechanical properties of them were calculated.
RESULTS: The human labrum specimen elastic modulus showed a significant inverse correlation with UTE-T2* (R=-0.67, P<0.05) and with UTE-T1 (R=-0.56, P=0.05). The stiffness of the specimens showed significant inverse correlations with UTE-T2* (R=-0.53, P=0.05) and UTE-T1 (R=-0.63, P=0.02).
CONCLUSION: This study highlighted the potential of UTE-MRI techniques for the mechanical assessment of the acetabular labrum. UTE-MRI may improve labrum degeneration detection and monitoring, which requires further investigations.