Gaceta medica de Mexico · 2025
Sex hormones, obstetric and gynecologic characteristics of multiple sclerosis women with and without relapse.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Espinoza-López Dulce A, Huerta-Franco María R, Zermeño-Pöhls Fernando, Fernández-Aguilar Ángeles, Marquez-Romero Juan M
Аннотация
BACKGROUND: Several studies show evidence of the relationship between sex hormone (SH) levels and Multiple Sclerosis (MS).
OBJECTIVE: To describe serum SH levels and gynecological and obstetric characteristics of women with MS in remission and relapse.
MATERIAL AND METHODS: This was a cross-sectional study. Gynecological, obstetric, clinical and laboratory measurements were analyzed. Serum determinations included 17b-estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, testosterone, and dehydroepiandrosterone.
RESULTS: Eighty-nine patients were studied, with a mean age of 35.33 ± 9.5 and a mean age of 12.7 ± 1.7 menarche. 65.2% reported regular menstrual cycles (MC), 25.9% reported irregular MC, and 11 postmenopausal patients. Twenty-six patients experienced one or more miscarriages, 37 patients were nulligravidae, and in those who reported pregnancies, the median was two. Thirty-six patients were evaluated during a relapse; 22 of these patients had regular MC, and 59.1% of relapses occurred during the follicular phase. There was no difference in serum HS levels when compared between relapsed and non-relapsed groups.
CONCLUSIONS: There is a high frequency of irregular MCs and abortions in this sample of women with MS. In patients with regular BC, relapses occurred most frequently during the follicular phase.
OBJECTIVE: To describe serum SH levels and gynecological and obstetric characteristics of women with MS in remission and relapse.
MATERIAL AND METHODS: This was a cross-sectional study. Gynecological, obstetric, clinical and laboratory measurements were analyzed. Serum determinations included 17b-estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, testosterone, and dehydroepiandrosterone.
RESULTS: Eighty-nine patients were studied, with a mean age of 35.33 ± 9.5 and a mean age of 12.7 ± 1.7 menarche. 65.2% reported regular menstrual cycles (MC), 25.9% reported irregular MC, and 11 postmenopausal patients. Twenty-six patients experienced one or more miscarriages, 37 patients were nulligravidae, and in those who reported pregnancies, the median was two. Thirty-six patients were evaluated during a relapse; 22 of these patients had regular MC, and 59.1% of relapses occurred during the follicular phase. There was no difference in serum HS levels when compared between relapsed and non-relapsed groups.
CONCLUSIONS: There is a high frequency of irregular MCs and abortions in this sample of women with MS. In patients with regular BC, relapses occurred most frequently during the follicular phase.