Experimental and therapeutic medicine · 2019
Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Yaolong, Ma Zhaoxia, Zheng Yuanyuan, Liu Baoling, Bao Pengfei, Wu Xingfei, Yu Congtao, Wen Zhengqi, Ma Tiekun, Liu Jinxue, Liu Change, Ma Daiping, Wu Haiying, Li Jun, Yuan Yong, Lu Ning, Zhao Hongbin, Li Yanjiao, Yang Suping, Zhang Rongping, Dai Jiejie, Hu Min
Аннотация
Osteoporosis (OP) treatment has always been challenging for elderly menopausal females. An animal model with a closer genetic association to human OP is essential for treatment research. Given its close genetic association to primates, the tree shrew is a suitable candidate for meeting the requirements for such an animal model. In the present study, a tree shrew OP model induced by ovariectomy (OVX), was established. Evaluation by multiple analysis methods, including blood biochemical indicators, uterus coefficients, micro-computed tomography analysis, histochemical analysis and scanning electron microscopic observation indicated that OVX was an appropriate method to establish the OP model in tree shrews. In addition, the biomolecular characteristics of OVX-induced osteoporosis were also assessed by transcriptome sequencing and bioinformatics analysis. The present study provides the methods used to confirm the successful establishment of the OP model in tree shrew, and suggests that the OP model is appropriate for human OP research.