[How is bone remodeling regulated?].

Bone remodeling is a concept of the biological process that maintains bone mass and its structure constantly and continuously. Several segments that constitute bone remodeling have been precisely investigated to reveal their cellular and molecular mechanisms in detail. Bone remodeling as unity, however, stands far away from our complete understanding. Disturbances in bone remodeling usually give rise to bone loss that causes several skeletal diseases, such as osteoporosis. To elucidate how bone remodeling is regulated and to understand what disorders in it are involved in each skeletal disease are important issues to be addressed in the field of bone biology.