Дисартрийская оценка у многих пациентов склероза.
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Ranucci Davide, Falco Fabrizia, Nicolella Valerio, Marra Ludovica Anna, Caracciolo Federica, Migliaccio Laura, Corsini Giuseppe, Esposito Antonio, Castiello Alessia, Petracca Maria, Moccia Marcello, Brescia Morra Vincenzo, Lanzillo Roberta, Carotenuto Antonio
Аннотация
Оригинал публикации
Dysarthria assessment in multiple sclerosis patients.
BACKGROUND: Speech patterns in multiple sclerosis (MS) are poorly characterized. Software such as Dysarthria Analyzer (DA) performs a detailed speech analysis.
OBJECTIVE: The objective of the study is (1) to explore speech features in patients with MS and (2) to investigate correlations between speech features and clinic-demographic characteristics.
METHODS: Patients underwent clinical assessments (Expanded Disability Status Scale (EDSS) and Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)) and speech evaluation using the DA. Each patient performed 6 vocal tasks: phonation A, phonation I, reading, monologue, fast syllables repetitions. The DA extracted 23 speech features as age-, gender-, and education-adjusted z-scores against healthy controls. A principal component analysis was conducted. Correlations between the components and clinic-demographic features were assessed through stepwise analysis.
RESULTS: We enrolled 72 patients (50 females; mean age 48.1 ± 10.9 years; median EDSS of 3 (1.5-6.5)). Principal component analysis (PCA) identified a 7-component model: Voice Intensity, Voice Intensity Variation, Motor Coordination, Speech Diadochokinesis, Speech Speed, Voice Strength, Speech Latency. Higher EDSS is associated with worse Voice Intensity Variation (r = -0.23; p = 0.05), Speech Speed (r = -0.40; p = 0.001) and Speech Latency (r = -0.23; p = 0.05). Progressive MS patients showed worse Voice Intensity Variation (coeff. = -1.20; p = 0.002). Worse cognitive functioning correlated with worse Speech Speed (coeff. = -0.38; p = 0.02).
CONCLUSION: Detailed speech analysis can reveal useful clinical information about physical and cognitive disability in MS possibly representing an additional tool to assess disability.