Proceedings of the National Academy of Sciences of the United States of America · 2022
Developmentally distinct CD4+ Treg lineages shape the CD8+ T cell response to acute Listeria infection.
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Dolina Joseph S, Lee Joey, Moore Eugene L, Hope Jennifer L, Gracias Donald T, Matsutani Takaji, Chawla Ashu, Greenbaum Jason A, Linden Joel, Schoenberger Stephen P
Аннотация
SignificanceThe CD4+ Treg response following acute Listeria infection is heterogeneous and deploys two distinct modes of suppression coinciding with initial pathogen exposure and resolution of infection. This bimodal suppression of CD8+ T cells during priming and contraction is mediated by separate Treg lineages. These findings make a significant contribution to our understanding of the functional plasticity inherent within Tregs, which allows these cells to serve as a sensitive and dynamic cellular rheostat for the immune system to prevent autoimmune pathology in the face of inflammation attendant to acute infection, enable expansion of the pathogen-specific response needed to control the infection, and reestablish immune homeostasis after the threat has been contained.