American journal of infection control · 2026
Incidence of latent TB infection among hospital contacts in an intermediate-burden country.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ryu Seung Hee, Lee Jin-Ju, Lim Young-Ju, Kim Jeeyoon, Jung Jiwon, Jo Kyung-Wook, Shim Tae Sun, Chong Yong Pil
Аннотация
BACKGROUND: This study aimed to investigate the incidence of latent tuberculosis infection (LTBI) and conversion rate among hospital inpatients contacts using an interferon-gamma release assay (IGRA)-based contact tracing strategy.
METHODS: We conducted a retrospective study at a 2,700-bed tertiary hospital in Seoul, South Korea. Data from January 2019 to December 2024 were reviewed. Contacts were recommended to undergo IGRA testing at the time of exposure (baseline) and again at ≥ 6 weeks later after exposure.
RESULTS: A total of 109 index cases required contact tracing, yielding 902 contacts, of whom 360 underwent IGRA testing between 1 and 6 months post-exposure (median, 48 days [interquartile range, 25-83]). At baseline, 79 (22%) tested IGRA-positive. Among 133 initially IGRA-negative individuals who underwent serial testing, 18 (14%) demonstrated IGRA conversion. Overall, 97 (27%) were diagnosed with LTBI.
CONCLUSIONS: Hospital-based contact investigation identified a substantial burden of latent TB infection among exposed individuals. IGRA conversion, rather than baseline positivity, may serve as a more reliable indicator of recent transmission in high or intermediate-burden settings, supporting the importance of serial testing in health care-associated TB exposure.
METHODS: We conducted a retrospective study at a 2,700-bed tertiary hospital in Seoul, South Korea. Data from January 2019 to December 2024 were reviewed. Contacts were recommended to undergo IGRA testing at the time of exposure (baseline) and again at ≥ 6 weeks later after exposure.
RESULTS: A total of 109 index cases required contact tracing, yielding 902 contacts, of whom 360 underwent IGRA testing between 1 and 6 months post-exposure (median, 48 days [interquartile range, 25-83]). At baseline, 79 (22%) tested IGRA-positive. Among 133 initially IGRA-negative individuals who underwent serial testing, 18 (14%) demonstrated IGRA conversion. Overall, 97 (27%) were diagnosed with LTBI.
CONCLUSIONS: Hospital-based contact investigation identified a substantial burden of latent TB infection among exposed individuals. IGRA conversion, rather than baseline positivity, may serve as a more reliable indicator of recent transmission in high or intermediate-burden settings, supporting the importance of serial testing in health care-associated TB exposure.