Active Cone Regeneration Following Autologous Internal Limiting Membrane 'Chunk' Transplantation in Optic Disc Pit-Associated Maculopathy.

This case report aims to study active cone regeneration and its functional correlation in optic disc pit maculopathy (ODPM) with a large outer macular defect treated with autologous internal limiting membrane (ILM) "chunk" transplantation. Outcome analysis was done using spectral-domain optical coherence tomography (SD-OCT), adaptive optics, and microperimetry. Visual acuity improved from counting fingers at 2 meters to 6/18 Snellen equivalent postoperatively, whereas SD-OCT demonstrated closure of outer subfoveal defect. Adaptive optics imaging revealed maximum active cone concentration of 14,232/mm2 at the fovea, and fixation stability improved to 61% and 90% (P1 and P2, respectively) on microperimetry. To conclude, autologous ILM "chunk" transplantation provides an additional therapeutic option in treatment of ODPM with large outer macular defect. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:152-155.].