PloS one · 2018
Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Furukawa Hiroshi, Oka Shomi, Shimada Kota, Hashimoto Atsushi, Komiya Akiko, Tsunoda Shinichiro, Suda Akiko, Ito Satoshi, Saisho Koichiro, Katayama Masao, Shinohara Satoshi, Sato Takeo, Nagatani Katsuya, Minota Seiji, Matsui Toshihiro, Fukui Naoshi, Sugii Shoji, Sano Hajime, Migita Kiyoshi, Nagaoka Shouhei, Tohma Shigeto
Аннотация
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations.
METHODS: Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.
RESULTS: In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16-1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19-1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected.
CONCLUSION: The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.
METHODS: Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.
RESULTS: In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16-1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19-1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected.
CONCLUSION: The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.