The Journal of craniofacial surgery · 2013
Cell therapy in bisphosphonate-related osteonecrosis of the jaw.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Gonzálvez-García Mar, Rodríguez-Lozano Francisco Javier, Villanueva Victor, Segarra-Fenoll Daniel, Rodríguez-González Maria Angeles, Oñate-Sánchez Ricardo, Blanquer Miguel, Moraleda José María
Аннотация
OBJECTIVE: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition found in patients who have received intravenous or oral bisphosphonate therapy for various diseases related to bone. This report describes a novel treatment of BRONJ using autologous bone marrow stem cells, platelet-rich plasma, beta tricalcium phosphate, and demineralized bone matrix.
STUDY DESIGN: We report a 71-year-old woman with history of multiple myeloma treated with intravenous zoledronic acid during 4 years. After a tooth extraction, the patient presented with a painful BRONJ lesion with no healing wound and cortical bone exposure. The patient was surgically managed with a standardized protocol of autologous stem cell therapy combining bone marrow harvest, cell concentration procedures, and intraoral surgery.
RESULTS: CT scan performed 6 months later showed improvement of bone and concentric ossification. Cellular therapy might be considered a new strategy to heal BRONJ lesions.
STUDY DESIGN: We report a 71-year-old woman with history of multiple myeloma treated with intravenous zoledronic acid during 4 years. After a tooth extraction, the patient presented with a painful BRONJ lesion with no healing wound and cortical bone exposure. The patient was surgically managed with a standardized protocol of autologous stem cell therapy combining bone marrow harvest, cell concentration procedures, and intraoral surgery.
RESULTS: CT scan performed 6 months later showed improvement of bone and concentric ossification. Cellular therapy might be considered a new strategy to heal BRONJ lesions.
Предметные рубрики MeSH
AgedAutograftsBiocompatible MaterialsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsBone Marrow TransplantationBone MatrixBone RegenerationBone SubstitutesCalcium PhosphatesDebridementDiphosphonatesFemaleFollow-Up StudiesHumansImidazolesInjections, IntravenousMandibular DiseasesMultiple MyelomaPlatelet-Rich PlasmaStem Cell TransplantationZoledronic Acid