Vitamin D and Vitamin K: Synergistic Roles and Emerging Evidence for Combined Supplementation.

The synergistic role of Vitamin D (VD) and Vitamin K (VK) in maintaining skeletal and cardiovascular health has garnered increasing scientific interest. While VD is well known for its role in calcium metabolism, VK, particularly its K2 isoform, ensures that calcium is deposited in bones and not in soft tissues. Recent evidence suggests that the interplay between these two fat-soluble vitamins may have significant implications for bone health, vascular integrity, and chronic disease prevention. This editorial explores current research on their combined supplementation, potential therapeutic benefits, and the caution warranted in clinical practice.