Bone · 2025
Association between advanced glycation end products and bone mineral density in Mexican population.
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Aparicio-Bautista Diana I, Salmerón Jorge, Jiménez-Ortega Rogelio F, López-Pérez Tania V, Becerra-Cervera Adriana, Velázquez-Cruz Rafael, Rivera-Paredez Berenice
Аннотация
BACKGROUND: Evidence shows that advanced glycation end products (AGEs) play a key role in skeletal deterioration by impacting bone quality and strength. However, there is limited long-term research on their association with bone mineral density (BMD), especially among different sexes and age groups.
OBJECTIVE: To evaluate the longitudinal association between serum AGEs and BMD in adults, stratified by sex and age groups (<45 years and ≥45 years).
METHODS: We conducted a longitudinal analysis using data from 1138 adults enrolled in the Health Workers Cohort Study, followed over a six-year period (2004-2010). BMD (g/cm2) was measured at various skeletal sites using dual-energy X-ray absorptiometry. Generalized estimating equations (GEE) and fixed-effects models were employed, stratified by sex and age group, and adjusted for potential confounders.
RESULTS: In GEE models, a 100 μU/mL increase in AGEs was significantly associated with lower BMD at the hip, femoral neck, and lumbar spine in women aged ≥45 years (β = -0.003, β = -0.004, β = -0.011, respectively). Among men ≥45 years, higher AGEs were also associated with lower BMD at the hip and femoral neck (β = -0.004 and β = -0.006, respectively). In women <45 years, AGEs were inversely associated with hip and femoral neck BMD (β = -0.003 for both). Fixed-effects models yielded consistent results, particularly among women ≥45 years. No significant associations were observed in men <45 years.
CONCLUSIONS: Elevated serum AGEs levels are associated with lower BMD over time, particularly among women. These findings suggest a potential role of AGEs in bone deterioration and their relevance in clinical risk assessment.
OBJECTIVE: To evaluate the longitudinal association between serum AGEs and BMD in adults, stratified by sex and age groups (<45 years and ≥45 years).
METHODS: We conducted a longitudinal analysis using data from 1138 adults enrolled in the Health Workers Cohort Study, followed over a six-year period (2004-2010). BMD (g/cm2) was measured at various skeletal sites using dual-energy X-ray absorptiometry. Generalized estimating equations (GEE) and fixed-effects models were employed, stratified by sex and age group, and adjusted for potential confounders.
RESULTS: In GEE models, a 100 μU/mL increase in AGEs was significantly associated with lower BMD at the hip, femoral neck, and lumbar spine in women aged ≥45 years (β = -0.003, β = -0.004, β = -0.011, respectively). Among men ≥45 years, higher AGEs were also associated with lower BMD at the hip and femoral neck (β = -0.004 and β = -0.006, respectively). In women <45 years, AGEs were inversely associated with hip and femoral neck BMD (β = -0.003 for both). Fixed-effects models yielded consistent results, particularly among women ≥45 years. No significant associations were observed in men <45 years.
CONCLUSIONS: Elevated serum AGEs levels are associated with lower BMD over time, particularly among women. These findings suggest a potential role of AGEs in bone deterioration and their relevance in clinical risk assessment.