The role of taurine in bone metabolism.

Bone metabolism is a dynamic process involving remodeling and rebuilding bone tissue. Important participants in this process include osteoblasts and osteoclasts, which may promote bone formation and bone resorption, respectively. Cumulative evidence suggests that taurine, a sulfur-containing nonessential amino acid, can regulate bone formation, bone resorption, and bone immunity through anti-inflammatory and antioxidant properties in bone metabolic diseases. However, the potential mechanisms by which taurine regulates bone metabolism remain unclear. This review focuses on the potential role of taurine in bone metabolic diseases, particularly osteoporosis and rheumatoid arthritis. Moreover, the regulatory mechanisms of taurine on bone formation, bone resorption, and bone immunity are summarized, which provides a theoretical basis for the application of taurine as a therapeutic agent to improve bone metabolic diseases.