Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2011
Agreement on a pandemic influenza preparedness framework for the sharing of viruses and benefit sharing.
НовостьНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhao Lili, Du Shushu, Xu Wenqi, Shi Xiaofei, Liu Rongzeng
Аннотация
BACKGROUND: Variations in the TLR9 gene have been associated with several autoimmune disorders, but the relationship between TLR9 polymorphisms and systemic lupus erythematosus (SLE) remains controversial. This study aims to evaluate the potential association between three single-nucleotide polymorphisms (SNPs) within the TLR9 gene and susceptibility to SLE in the Han Chinese female population.
METHODS: A total of 150 SLE patients and 151 healthy controls of Han Chinese ethnicity were enrolled. Genotyping of TLR9 was performed using sequence-specific primer (SSP) polymerase chain reaction and validated by Sanger sequencing. Associations between the SNPs and SLE susceptibility were analyzed using the chi-square test or Fisher's exact test. Additionally, correlations between the SNPs and clinical manifestations of SLE were assessed.
RESULTS: The TLR9 rs352139 polymorphism was significantly associated with increased SLE susceptibility in heterozygous (AG vs. AA, OR = 1.79, 95% CI [1.07-2.99], p = 0.025), homozygous (GG vs. AA, OR = 2.11, 95% CI [1.06-4.19], p = 0.033), dominant (GG+AG vs. AA, OR = 1.86, 95% CI [1.15-3.03], p = 0.012), and allele (G vs. A, OR = 1.49, 95% CI [1.07-2.06], p = 0.017) models. Similarly, rs352140 was significantly associated with SLE risk in homozygous (TT vs. CC, OR = 2.47, 95% CI [1.23-4.96], p = 0.010), recessive (TT vs. CC+CT, OR = 2.57, 95% CI [1.35-4.88], p = 0.003), and allele (T vs. C, OR = 1.43, 95% CI [1.03-1.99], p = 0.031) models. Haplotype analysis revealed that haplotype HT1 (C/A/T) had a protective effect against SLE (OR = 0.70, 95% CI [0.506-0.966], p = 0.030), while haplotype HT2 (T/G/T) was positively associated with increased susceptibility (OR = 1.505, 95% CI [1.068-2.121], p = 0.019).
CONCLUSIONS: These findings suggest that the TLR9 rs352139 and rs352140 polymorphisms are significantly associated with increased susceptibility to SLE in the Han Chinese population, indicating a potential role of TLR9 in the pathogenesis of SLE.
METHODS: A total of 150 SLE patients and 151 healthy controls of Han Chinese ethnicity were enrolled. Genotyping of TLR9 was performed using sequence-specific primer (SSP) polymerase chain reaction and validated by Sanger sequencing. Associations between the SNPs and SLE susceptibility were analyzed using the chi-square test or Fisher's exact test. Additionally, correlations between the SNPs and clinical manifestations of SLE were assessed.
RESULTS: The TLR9 rs352139 polymorphism was significantly associated with increased SLE susceptibility in heterozygous (AG vs. AA, OR = 1.79, 95% CI [1.07-2.99], p = 0.025), homozygous (GG vs. AA, OR = 2.11, 95% CI [1.06-4.19], p = 0.033), dominant (GG+AG vs. AA, OR = 1.86, 95% CI [1.15-3.03], p = 0.012), and allele (G vs. A, OR = 1.49, 95% CI [1.07-2.06], p = 0.017) models. Similarly, rs352140 was significantly associated with SLE risk in homozygous (TT vs. CC, OR = 2.47, 95% CI [1.23-4.96], p = 0.010), recessive (TT vs. CC+CT, OR = 2.57, 95% CI [1.35-4.88], p = 0.003), and allele (T vs. C, OR = 1.43, 95% CI [1.03-1.99], p = 0.031) models. Haplotype analysis revealed that haplotype HT1 (C/A/T) had a protective effect against SLE (OR = 0.70, 95% CI [0.506-0.966], p = 0.030), while haplotype HT2 (T/G/T) was positively associated with increased susceptibility (OR = 1.505, 95% CI [1.068-2.121], p = 0.019).
CONCLUSIONS: These findings suggest that the TLR9 rs352139 and rs352140 polymorphisms are significantly associated with increased susceptibility to SLE in the Han Chinese population, indicating a potential role of TLR9 in the pathogenesis of SLE.