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DOI 10.1038/s42255-025-01296-9

Медицинская библиотека · Nature metabolism · 2025

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.

Loft Anne, Emont Margo P, Weinstock Ada, Divoux Adeline, Ghosh Adhideb, Wagner Allon, Hertzel Ann V, Maniyadath Babukrishna, Deplancke Bart, Liu Boxiang, Scheele Camilla, Lumeng Carey, Ding Changhai, Ma Chenkai, Wolfrum Christian, Strieder-Barboza Clarissa, Li Congru, Truong Danh D, Bernlohr David A, Stener-Victorin Elisabet, Kershaw Erin E, Yeger-Lotem Esti, Shamsi Farnaz, Hui Hannah X, Camara Henrique, Zhong Jiawei, Kalucka Joanna, Ludwig Joseph A, Semon Julie A, Jalkanen Jutta, Whytock Katie L, Dumont Kyle D, Sparks Lauren M, Muir Lindsey A, Fang Lingzhao, Massier Lucas, Saraiva Luis R, Beyer Marc D, Jeschke Marc G, Mori Marcelo A, Boroni Mariana, Walsh Martin J, Patti Mary-Elizabeth, Lynes Matthew D, Blüher Matthias, Rydén Mikael, Hamda Natnael, Solimini Nicole L, Mejhert Niklas, Gao Peng, Gupta Rana K, Murphy Rinki, Pirouzpanah Saeed, Corvera Silvia, Tang Su'an, Das Swapan K, Schmidt Søren F, Zhang Tao, Nelson Theodore M, O'Sullivan Timothy E, Efthymiou Vissarion, Wang Wenjing, Tong Yihan, Tseng Yu-Hua, Mandrup Susanne, Rosen Evan D

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Аннотация

Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.

Для цитирования: Loft Anne, Emont Margo P, Weinstock Ada, Divoux Adeline, Ghosh Adhideb, Wagner Allon, Hertzel Ann V, Maniyadath Babukrishna, Deplancke Bart, Liu Boxiang, Scheele Camilla, Lumeng Carey, Ding Changhai, Ma Chenkai, Wolfrum Christian, Strieder-Barboza Clarissa, Li Congru, Truong Danh D, Bernlohr David A, Stener-Victorin Elisabet, Kershaw Erin E, Yeger-Lotem Esti, Shamsi Farnaz, Hui Hannah X, Camara Henrique, Zhong Jiawei, Kalucka Joanna, Ludwig Joseph A, Semon Julie A, Jalkanen Jutta, Whytock Katie L, Dumont Kyle D, Sparks Lauren M, Muir Lindsey A, Fang Lingzhao, Massier Lucas, Saraiva Luis R, Beyer Marc D, Jeschke Marc G, Mori Marcelo A, Boroni Mariana, Walsh Martin J, Patti Mary-Elizabeth, Lynes Matthew D, Blüher Matthias, Rydén Mikael, Hamda Natnael, Solimini Nicole L, Mejhert Niklas, Gao Peng, Gupta Rana K, Murphy Rinki, Pirouzpanah Saeed, Corvera Silvia, Tang Su'an, Das Swapan K, Schmidt Søren F, Zhang Tao, Nelson Theodore M, O'Sullivan Timothy E, Efthymiou Vissarion, Wang Wenjing, Tong Yihan, Tseng Yu-Hua, Mandrup Susanne, Rosen Evan D. Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.. Nature metabolism. 2025. DOI: 10.1038/s42255-025-01296-9.

Предметные рубрики MeSH

AnimalsHumansMiceAdipocytesAdipose TissueAtlases as TopicSingle-Cell Analysis
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