Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2003
Levels of fibroblast growth factor 2 in synovial fluids in human patients with internal derangement of the temporomandibular joint.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sato Jun, Segami Natsuki, Kaneyama Keiseki, Konishi Hiroaki, Yoshitake Yoshino, Nishikawa Katsuzo
Аннотация
OBJECTIVE: We sought to elucidate the levels of fibroblast growth factor 2 (FGF-2) in synovial fluid taken from internally deranged human temporomandibular joints (TMJs) and to discuss the role of FGF-2 in the pathogenesis of internal derangement.
STUDY DESIGN: Through the use of a pumping procedure, diluted synovial fluid was collected from the upper joint compartment of 22 TMJs with evidence of internal derangement (21 patients) and 8 TMJs with no such evidence (5 control subjects). Two of the control subjects were patients who had habitual dislocation, and three were healthy volunteers. The level of FGF-2 in the synovial fluid was assessed by means of an enzyme-linked immunosorbent assay.
RESULTS: FGF-2 levels were at detectable levels in 15 of the 22 TMJs (68%) with internal derangement. The mean concentration of FGF-2 was 24 pg/mL. In the control group, FGF-2 levels were detectable in only 1 of 8 joints (13%), for a concentration of 3 pg/mL. The mean concentration of FGF-2 in the synovial fluid was significantly higher in the internal derangement group than in the control group (P =.02).
CONCLUSIONS: FGF-2 levels are elevated in the human synovial fluid of TMJs with internal derangement.
STUDY DESIGN: Through the use of a pumping procedure, diluted synovial fluid was collected from the upper joint compartment of 22 TMJs with evidence of internal derangement (21 patients) and 8 TMJs with no such evidence (5 control subjects). Two of the control subjects were patients who had habitual dislocation, and three were healthy volunteers. The level of FGF-2 in the synovial fluid was assessed by means of an enzyme-linked immunosorbent assay.
RESULTS: FGF-2 levels were at detectable levels in 15 of the 22 TMJs (68%) with internal derangement. The mean concentration of FGF-2 was 24 pg/mL. In the control group, FGF-2 levels were detectable in only 1 of 8 joints (13%), for a concentration of 3 pg/mL. The mean concentration of FGF-2 in the synovial fluid was significantly higher in the internal derangement group than in the control group (P =.02).
CONCLUSIONS: FGF-2 levels are elevated in the human synovial fluid of TMJs with internal derangement.
Предметные рубрики MeSH
AdolescentAdultAgedArthroscopyBiopsyEnzyme-Linked Immunosorbent AssayFemaleFibroblast Growth Factor 2HumansJoint DislocationsMaleMiddle AgedPain MeasurementRange of Motion, ArticularStatistics, NonparametricSynovial FluidSynovial MembraneTemporomandibular JointTemporomandibular Joint DiscTemporomandibular Joint Disorders