Медицинская библиотека · Advances in rheumatology (London, England) · 2022

COVID-19 was not associated or trigger disease activity in spondylarthritis patients: ReumaCoV-Brasil cross-sectional data.

Marques Claudia Diniz Lopes, Ribeiro Sandra Lúcia Euzébio, Albuquerque Cleandro P, de Sousa Studart Samia Araujo, Ranzolin Aline, de Andrade Nicole Pamplona Bueno, Dantas Andrea T, Mota Guilherme D, Resende Gustavo G, Marinho Adriana O, Angelieri Danielle, Andrade Danieli, Ribeiro Francinne M, Omura Felipe, Silva Nilzio A, Rocha Junior Laurindo, Brito Danielle E, Fernandino Diana C, Yazbek Michel A, Souza Mariana P G, Ximenes Antonio Carlos, Martins Ana Silvia S, Castro Glaucio Ricardo W, Oliveira Lívia C, Freitas Ana Beatriz S B, Kakehasi Adriana M, Gomides Ana Paula M, Reis Neto Edgard Torres, Pileggi Gecilmara S, Ferreira Gilda A, Mota Licia Maria H, Xavier Ricardo M, de Medeiros Pinheiro Marcelo, ReumaCoV-Brasil Registry

Многоцентровое исследованиеСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVES

To evaluate the disease activity before and after COVID-19 and risk factors associated with outcomes, including hospitalization, intensive care unit (ICU) admission, mechanical ventilation (MV) and death in patients with spondylarthritis (SpA).

METHODS

ReumaCoV Brazil is a multicenter prospective cohort of immune-mediated rheumatic diseases (IMRD) patients with COVID-19 (case group), compared to a control group of IMRD patients without COVID-19. SpA patients enrolled were grouped as axial SpA (axSpA), psoriatic arthritis (PsA) and enteropathic arthritis, according to usual classification criteria.

RESULTS

353 SpA patients were included, of whom 229 (64.9%) were axSpA, 118 (33.4%) PsA and 6 enteropathic arthritis (1.7%). No significant difference was observed in disease activity before the study inclusion comparing cases and controls, as well no worsening of disease activity after COVID-19. The risk factors associated with hospitalization were age over 60 years (OR = 3.71; 95% CI 1.62-8.47, p = 0.001); one or more comorbidities (OR = 2.28; 95% CI 1.02-5.08, p = 0.001) and leflunomide treatment (OR = 4.46; 95% CI 1.33-24.9, p = 0.008). Not having comorbidities (OR = 0.11; 95% CI 0.02-0.50, p = 0.001) played a protective role for hospitalization. In multivariate analysis, leflunomide treatment (OR = 8.69; CI = 95% 1.41-53.64; p = 0.023) was associated with hospitalization; teleconsultation (OR = 0.14; CI = 95% 0.03-0.71; p = 0.01) and no comorbidities (OR = 0.14; CI = 95% 0.02-0.76; p = 0.02) remained at final model as protective factor.

CONCLUSIONS

Our results showed no association between pre-COVID disease activity or that SARS-CoV-2 infection could trigger disease activity in patients with SpA. Teleconsultation and no comorbidities were associated with a lower hospitalization risk. Leflunomide remained significantly associated with higher risk of hospitalization after multiple adjustments.

Для цитирования: Marques Claudia Diniz Lopes, Ribeiro Sandra Lúcia Euzébio, Albuquerque Cleandro P, de Sousa Studart Samia Araujo, Ranzolin Aline, de Andrade Nicole Pamplona Bueno, Dantas Andrea T, Mota Guilherme D, Resende Gustavo G, Marinho Adriana O, Angelieri Danielle, Andrade Danieli, Ribeiro Francinne M, Omura Felipe, Silva Nilzio A, Rocha Junior Laurindo, Brito Danielle E, Fernandino Diana C, Yazbek Michel A, Souza Mariana P G, Ximenes Antonio Carlos, Martins Ana Silvia S, Castro Glaucio Ricardo W, Oliveira Lívia C, Freitas Ana Beatriz S B, Kakehasi Adriana M, Gomides Ana Paula M, Reis Neto Edgard Torres, Pileggi Gecilmara S, Ferreira Gilda A, Mota Licia Maria H, Xavier Ricardo M, de Medeiros Pinheiro Marcelo, ReumaCoV-Brasil Registry. COVID-19 was not associated or trigger disease activity in spondylarthritis patients: ReumaCoV-Brasil cross-sectional data.. Advances in rheumatology (London, England). 2022. DOI: 10.1186/s42358-022-00268-x.

Предметные рубрики MeSH

Humans Middle Aged Cross-Sectional Studies Arthritis, Psoriatic COVID-19 Prospective Studies Leflunomide Brazil SARS-CoV-2 Spondylarthritis

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