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Войти в исследования Clinical biochemistry · 2008
Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis.
СтатьяНазвание и аннотация: Перевод в очереди
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Inui Naoki, Enomoto Noriyuki, Suda Takafumi, Kageyama Yasunori, Watanabe Hiroshi, Chida Kingo
Аннотация
OBJECTIVE: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis.
DESIGN AND METHODS: Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population.
RESULTS: No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis.
CONCLUSION: Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients.
DESIGN AND METHODS: Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population.
RESULTS: No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis.
CONCLUSION: Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients.