Multiple sclerosis journal - experimental, translational and clinical · 2025
Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Subhi Mustafa, Manukyan Sargis, Zabala Gabriela, Locke Laura, Guerrero Brooke, Kaisey Marwa, Khodabakhsh Afshin James, Carass Aaron, Prince Jerry L, Saidha Shiv, Calabresi Peter A, Sicotte Nancy L, Sati Pascal, Al-Louzi Omar
Аннотация
BACKGROUND: Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). Compared to absolute values, inter-eye differences (IED) account for variation in baseline structure and function before ON.
OBJECTIVES: To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON.
METHODS: In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy controls underwent optical coherence tomography, best-corrected visual acuity, 2.5% and 1.25% low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing.
RESULTS: Sixty-six participants with MSRD (33 with unilateral ON history, 33 without ON history) and 15 healthy controls were included. For the ON cohort, a GCIPL IED threshold of 6.5% was associated with dyschromatopsia (AUC = 0.76, p = 0.011), 11% with 1.25% LCLA IED of >5 letters (AUC = 0.75, p = 0.008), 13% with 2.5% LCLA IED of >5 letters (AUC = 0.86, p < 0.001), 15% with VFMD IED of >2 dB (AUC = 0.75, p = 0.031), and 27% with logarithm of minimum angle of resolution IED of >0.3 (AUC = 1.00, p < 0.001). These associations were more robust compared to other retinal layer IED.
CONCLUSIONS: GCIPL IED thresholds more accurately reflect multimodal visual dysfunction after ON compared to other retinal layer IED.
OBJECTIVES: To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON.
METHODS: In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy controls underwent optical coherence tomography, best-corrected visual acuity, 2.5% and 1.25% low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing.
RESULTS: Sixty-six participants with MSRD (33 with unilateral ON history, 33 without ON history) and 15 healthy controls were included. For the ON cohort, a GCIPL IED threshold of 6.5% was associated with dyschromatopsia (AUC = 0.76, p = 0.011), 11% with 1.25% LCLA IED of >5 letters (AUC = 0.75, p = 0.008), 13% with 2.5% LCLA IED of >5 letters (AUC = 0.86, p < 0.001), 15% with VFMD IED of >2 dB (AUC = 0.75, p = 0.031), and 27% with logarithm of minimum angle of resolution IED of >0.3 (AUC = 1.00, p < 0.001). These associations were more robust compared to other retinal layer IED.
CONCLUSIONS: GCIPL IED thresholds more accurately reflect multimodal visual dysfunction after ON compared to other retinal layer IED.