Nature biomedical engineering · 2022
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Spang Martin T, Middleton Ryan, Diaz Miranda, Hunter Jervaughn, Mesfin Joshua, Banka Alison, Sullivan Holly, Wang Raymond, Lazerson Tori S, Bhatia Saumya, Corbitt James, D'Elia Gavin, Sandoval-Gomez Gerardo, Kandell Rebecca, Vratsanos Maria A, Gnanasekaran Karthikeyan, Kato Takayuki, Igata Sachiyo, Luo Colin, Osborn Kent G, Gianneschi Nathan C, Eniola-Adefeso Omolola, Cabrales Pedro, Kwon Ester J, Contijoch Francisco, Reeves Ryan R, DeMaria Anthony N, Christman Karen L
Аннотация
Decellularized extracellular matrix in the form of patches and locally injected hydrogels has long been used as therapies in animal models of disease. Here we report the safety and feasibility of an intravascularly infused extracellular matrix as a biomaterial for the repair of tissue in animal models of acute myocardial infarction, traumatic brain injury and pulmonary arterial hypertension. The biomaterial consists of decellularized, enzymatically digested and fractionated ventricular myocardium, localizes to injured tissues by binding to leaky microvasculature, and is largely degraded in about 3 d. In rats and pigs with induced acute myocardial infarction followed by intracoronary infusion of the biomaterial, we observed substantially reduced left ventricular volumes and improved wall-motion scores, as well as differential expression of genes associated with tissue repair and inflammation. Delivering pro-healing extracellular matrix by intravascular infusion post injury may provide translational advantages for the healing of inflamed tissues 'from the inside out'.