The relationship between Interleukin 1 beta single nucleotide polymorphisms and systemic lupus erythematosus among the Chinese Han population.

OBJECTIVE

Systemic lupus erythematosus (SLE) is a typical autoimmune disease whose etiology is related to genetic factors. This study is designed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) of the Interleukin 1 beta (IL-1β) gene (rs16944, rs1143627, rs1143634) and SLE susceptibility and clinical characteristics in the Chinese Han population.

METHODS

This case-control study recruited 155 SLE patients and 140 controls. DNA was extracted from the venous blood of all subjects and genotyped using PCR and mass spectrometry.

RESULTS

Individuals with at least one mutant gene G (AG+GG genotype) at rs16944, at least one mutant gene A (AG+AA genotype) at rs1143627 and the AG Genotype at rs1143634 were associated with a lower risk of SLE compared to healthy controls(P = 0.009; P = 0.005; P = 0.016). The AG genotype at rs16944 increased the risk of anti-SSA(Ro) antibody positivity and thrombocytopenia (P = 0.033; P = 0.018), while the G allele decreased the risk of lupus nephritis (P = 0.040). For rs1143627, the A allele was linked with an increased risk of LA2 positivity for lupus anticoagulant (P = 0.041) and a lower risk of lupus nephritis (P = 0.044), and the AG genotype was associated with an increased risk of thrombocytopenia (P = 0.009). There was no correlation between rs1143634 and clinical features of SLE.

CONCLUSION

In conclusion, IL-1β gene polymorphisms are related to SLE susceptibility and clinical features in the Chinese population.