A community-based study of the relationship between coronary artery disease and osteoporosis in Chinese postmenopausal women.

BACKGROUND

Menopause is associated with an increased risk for osteoporosis (OP) and coronary artery disease (CAD). The goal of this study was to seek the possible relationship between CAD and OP in Chinese postmenopausal women.

PATIENTS AND

METHODS

The total of 1825 participants with complete records were available for data analysis in this study. CAD was diagnosed if any one of the following was present: (i) history and/or treatment for angina and/or myocardial infarction; (ii) history of coronary artery revascularization procedures and/or coronary angiography with 50% or more stenosis in one or more of the major coronary arteries; and (iii) regional wall-motion abnormalities on rest echocardiography. OP was defined as T-score less than -2.5. Multiple regression models after controlling for confounding factors were performed to detect their relationships.

RESULTS

The multiple variable linear regression analyses failed to show a significant association between CAD and T-score. However, the multivariate logistic regression analyses after adjustment for relevant confounding factors detected significant associations between CAD and OP.

CONCLUSION

The present study provided data suggesting that CAD was independently and significantly associated with OP. The prevalence of OP was more frequent in Chinese postmenopausal women with CAD.