Предварительная инфекция коронавируса муринной нейронной нервы улучшает экспериментальный аутоиммунный энцефалит.
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Saxena Divyasha, Walter Kelly, Amona Elizabeth, Kong Maiying, Perlman Stanley, Zheng Jian
Аннотация
Оригинал публикации
Prior murine neurotropic coronavirus infection ameliorates experimental autoimmune encephalitis.
BACKGROUND: Central nervous system (CNS) infections contribute to the development of neuroinflammation and neurodegenerative diseases. However, the mechanisms underlying the correlation between CNS infection and subsequent inflammatory course remain largely unknown.
METHODS: Here, we addressed this question by infecting mice with a sublethal dose of a well-studied neurotropic coronavirus, mouse hepatitis virus (MHV), and investigated the effects of infection on the subsequent induction of a mouse multiple sclerosis (MS) model (myelin oligodendrocyte glycoprotein 35-55 (MOG35-55) peptide-induced experimental autoimmune encephalitis (EAE)).
RESULTS: Unexpectedly, C57BL/6J mice that recovered from MHV infection showed alleviated clinical signs of induced EAE. Mechanistically, this protection is mediated by a novel CNS-resident Foxp3+ CD8 T cell population induced by interleukin (IL)-10, which was secreted by myeloid cells that infiltrated the MHV-infected CNS as part of the MHV-specific immune response. These Foxp3+ CD8 T cells ameliorated EAE severity by decreasing the quantity and function of autoreactive CD4 and CD8 T cell infiltrating CNS independent of antigen specificity, as well as by inhibiting the activation of microglia accumulating in the affected spinal cords (SCs). The persistence of these Foxp3+ CD8 T cells in the CNS may contribute to the long-term post-acute sequelae of infection.
CONCLUSION: This study reveals a novel post-infectious anti-inflammatory milieu that develops in MHV-infected CNS of MHV and leads to the generation of Foxp3+ CD8 regulatory T cells, thereby diminishing the progression of subsequent autoimmune disease.