Effectiveness of FDA vital staining in follow UP of DR PTB patients on longer treatment regimen under NTEP.

BACKGROUND

This high prevalent time of drug resistant tuberculosis need early finding of patients who are failing the longer treatment regimen, which can be done by using a simple method rather than using liquid culture which is expensive, consuming more time and technology.

METHODS

Prospective observational study of 116 diagnosed cases of DR PTB patients attending at RBIPMT hospital, from December 2020 to December 2021. After primary analysis patients were followed up at end of first six months of treatment to give 2 sputum samples for examination by both culture and FDA staining at Intermediate Reference Laboratory, Delhi.

RESULTS

Of 116 patients 57 were male and 59 were female, maximum in their 2nd to 4th decade of life. In all 6 months follow up, the relationship between the results of culture and FDA staining was found to be significant. After the end of 2nd month the diagnostic accuracy of FDA was almost 100%. Overall sensitivity of FDA staining was 79.25%, specificity was 98.87%, with diagnostic accuracy 97.08%.

CONCLUSIONS

FDA staining was found to be as effective as liquid culture in the follow up of drug resistant pulmonary tuberculosis patients on longer treatment regimen and will help not only in reducing the burden of DRTB in India but also saving the resources.