Ocular immunology and inflammation · 2018
Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients.
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Yu-Qin, Dai Xiao-Dan, Ran Yun, Cao Ying, Lan Chun-Lin, Guan Ji-Tian, Liu Chang, Yang Feng-Mei, Gan Yi-Jing, Liu Bai-Jing, Fang Ai-Wu, Lin Dan, Gong Xian-Hui, Cui Ren-Zhe, Jin Zi-Bing, Qu Jia, Lu Fan, Chi Zai-Long
Аннотация
Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity.Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls.Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values.Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.