Archives of osteoporosis · 2025
Utility of FRAX® and FRAXplus® in predicting prevalent radiographic vertebral fractures in postmenopausal women from a rural hospital in Southern India-FRACHAMB study (FRActure Christian Hospital AMBilikkai).
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cherian Jacob, Cherian Kripa Elizabeth, John Cynthia Susan, Vinodhini Dharmasivam, Minz Baren, Cherian Shiela, Esmy P O, Kuruvilla Vinay, Manoranjan Palanisamy, Paul Thomas V
Аннотация
UNLABELLED: In alignment with previous studies using the densitometric vertebral fracture assessment tool, the prevalence of radiographic moderate-severe vertebral fractures in rural postmenopausal women was 34%. FRAXplus could bring one additional woman to treatment intervention thresholds who may have otherwise been missed had additional risk factors not been captured.
PURPOSE: To study the prevalence of radiographic vertebral fractures and the utility of FRAXplus® and FRAX® in predicting prevalent vertebral fractures in rural southern India.
METHODS: This cross-sectional study involved 150 rural postmenopausal women, and they were assessed for radiographic vertebral fractures. FRAX® and FRAXplus® were utilized for computing a 10 year risk of major osteoporotic fractures (MOF) and hip fractures (HF) based on clinical risk factors.
RESULTS: The mean (SD) age of the patients was 66.1 (6.5) years and BMI (kg/m2) was 23.1 (4.4). The prevalence of moderate to severe vertebral fractures was 34%. Forty-four subjects had FRAX-MOF cutoff ≥ 10.5 and 57 had FRAX-HF cutoff ≥ 3.5. FRAXplus® correction was utilized in 34 subjects (23%) for falls (n = 30) and glucocorticoids (N = 4). One additional patient reached the treatment threshold for FRAX-MOF and FRAX-HF when FRAXplus® was utilized. On ROC analysis, a cutoff of 6 had a sensitivity of 80% and 40% specificity for FRAX-MOF, and a cutoff of 1.5 for FRAX-HF had a sensitivity of 76% and 40% specificity.
CONCLUSION: One-third of rural postmenopausal women had fragility fractures detected on a lateral spine X-ray. Although FRAX® at established Indian cut-offs does help in identifying most women who require anti-osteoporotic treatment, the utilization of FRAX plus® will help in further detecting women who are at borderline risk and may otherwise miss out on treatment if additional risk factors are not captured.
PURPOSE: To study the prevalence of radiographic vertebral fractures and the utility of FRAXplus® and FRAX® in predicting prevalent vertebral fractures in rural southern India.
METHODS: This cross-sectional study involved 150 rural postmenopausal women, and they were assessed for radiographic vertebral fractures. FRAX® and FRAXplus® were utilized for computing a 10 year risk of major osteoporotic fractures (MOF) and hip fractures (HF) based on clinical risk factors.
RESULTS: The mean (SD) age of the patients was 66.1 (6.5) years and BMI (kg/m2) was 23.1 (4.4). The prevalence of moderate to severe vertebral fractures was 34%. Forty-four subjects had FRAX-MOF cutoff ≥ 10.5 and 57 had FRAX-HF cutoff ≥ 3.5. FRAXplus® correction was utilized in 34 subjects (23%) for falls (n = 30) and glucocorticoids (N = 4). One additional patient reached the treatment threshold for FRAX-MOF and FRAX-HF when FRAXplus® was utilized. On ROC analysis, a cutoff of 6 had a sensitivity of 80% and 40% specificity for FRAX-MOF, and a cutoff of 1.5 for FRAX-HF had a sensitivity of 76% and 40% specificity.
CONCLUSION: One-third of rural postmenopausal women had fragility fractures detected on a lateral spine X-ray. Although FRAX® at established Indian cut-offs does help in identifying most women who require anti-osteoporotic treatment, the utilization of FRAX plus® will help in further detecting women who are at borderline risk and may otherwise miss out on treatment if additional risk factors are not captured.