The hyalinosis-associated 90 kD glycoprotein of human skin has lectin-like characteristics.

90 kD glycoprotein is a sialylated, mannose-rich protein which accumulates predominantly in the skin in massive hyalinosis. This study demonstrates that purified 90 kD glycoprotein induces agglutination of A, B and O red cells which is inhibitable by alpha-D-glucose and alpha-D-fucose. The binding of various 125I-labelled proteins to 90 kD glycoprotein is both carbohydrate and calcium dependent. The results show that 90 kD glycoprotein is a lectin-like carbohydrate-binding haemagglutinin.