Dermatomyositis: factors predicting relapse.

BACKGROUND

The course of dermatomyositis (DM) can be chronic with relapses, which are associated with major morbidity.

OBJECTIVE

The aim of this study was to identify presentation features that predict DM relapses.

METHODS

We retrospectively reviewed data of patients with DM recorded from 1990 to 2011, including muscle biopsy results. Characteristics of patients with and without relapses were compared. Hazard ratios (HRs) were estimated using a Cox model.

RESULTS

We identified 34 patients, with a mean age of 46 ± 17 years (range, 18-77) and 24 (71%) women. The muscle and skin abnormalities relapsed in 21 (61%) patients. By univariate analysis, two presentation features were significantly associated with a subsequently relapsing course, namely, dysphonia [HR = 3.2 (1.2-8.5)] and greater skin lesion severity defined as a Cutaneous Disease Area Severity Index [CDASI] > 20 [HR = 3.5 (1.2-7.9)].

CONCLUSION

Dysphonia and skin lesion severity at disease onset must be recorded, as they significantly predict a relapsing disease course.