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DOI 10.1016/j.tripleo.2010.05.067

Медицинская библиотека · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2010

Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series.

Epstein Matthew S, Wicknick Fredrick W, Epstein Joel B, Berenson James R, Gorsky Meir

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Аннотация

BACKGROUND

Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON).

METHODS

Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months.

RESULTS

A 74% decrease in area of bony exposure and symptom control was achieved in these cases.

DISCUSSION: Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.

Для цитирования: Epstein Matthew S, Wicknick Fredrick W, Epstein Joel B, Berenson James R, Gorsky Meir. Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series.. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010. DOI: 10.1016/j.tripleo.2010.05.067.

Предметные рубрики MeSH

Administration, OralAgedAged, 80 and overAnti-Infective Agents, LocalAntioxidantsBone Density Conservation AgentsChlorhexidineDiphosphonatesFemaleFollow-Up StudiesFree Radical ScavengersHumansInjections, IntravenousJaw DiseasesMaleMiddle AgedMouthwashesOsteonecrosisPentoxifyllinePhosphodiesterase InhibitorsTreatment Outcomealpha-Tocopherol
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