The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
Gout in Older Adults: The Atherosclerosis Risk in Communities Study.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Burke Bridget Teevan, Köttgen Anna, Law Andrew, Grams Morgan, Baer Alan N, Coresh Josef, McAdams-DeMarco Mara A
Аннотация
BACKGROUND: It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age.
METHODS: We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population-based cohort of middle-aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate-associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model.
RESULTS: The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 µmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age.
CONCLUSIONS: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.
METHODS: We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population-based cohort of middle-aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate-associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model.
RESULTS: The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 µmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age.
CONCLUSIONS: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.
Предметные рубрики MeSH
ATP Binding Cassette Transporter, Subfamily G, Member 2ATP-Binding Cassette TransportersAge FactorsAgedAtherosclerosisFemaleGlucose Transport Proteins, FacilitativeGoutHumansIncidenceMaleMiddle AgedNeoplasm ProteinsPolymorphism, Single NucleotidePrevalenceProspective StudiesRisk FactorsSurveys and QuestionnairesUnited StatesUric Acid