Роль взвешенных изображений в качестве заменителя постконтрастных изображений Т1 в обнаружении активных множественных склерозных повреждений.
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Rashad Ali F, Teiba M K, Sheha A S, Darwish E A F
Аннотация
Оригинал публикации
The role of susceptibility weighted imaging as a substitute to post-contrast T1-weighed images in detection of active multiple sclerosis lesions.
BACKGROUND AND PURPOSE: Magnetic susceptibility levels of multiple sclerosis plaques increase as they convert from the active enhancing stage to the chronic or inactive nonenhancing stages. The purpose of our study was to discern whether a qualitative evaluation of SWI signal intensity of MS lesions could act as a viable substitute for gadolinium-based contrast agents in differentiating acute and chronic lesions.
METHODS: In this retrospective study, 800 MS plaques from 76 patients were assessed. For each plaque its appearance on SWI was designated according to one of the following patterns (hypointense rings, marked hypointensity, mild hypointensity, iso-/hyperintensity). Postcontrast T1-weighted images were viewed to determine the presence or absence of contrast enhancement. The Chi-squared test was used to determine the association, if any, between each pattern on SWI and contrast enhancement.
RESULTS: No significant association was found between an iso/hyperintense signal on SWI and contrast enhancement (P=0.14). Marked hypointensity and hypointense rings were both significantly associated with the absence of contrast enhancement (P < 0.0001) whereas, mild hypointensity was significantly associated with presence of enhancement (P < 0.0001) CONCLUSIONS: Though this study demonstrated the presence of a significant relationship between several SWI signal patterns and the presence or absence of contrast enhancement, the lack of association between iso/hyperintense signal on SWI and contrast enhancement meant that a large proportion of enhancing active lesions and chronic silent lesions appeared identical on SWI, greatly hindering its ability in differentiating acute and chronic lesions.