Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2010
Treatment outcomes in patients with bisphosphonate-related osteonecrosis of the jaws: a prospective study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Scoletta Matteo, Arduino Paolo G, Dalmasso Paola, Broccoletti Roberto, Mozzati Marco
Аннотация
OBJECTIVES: The aim of this study was to evaluate the 2-year success rate of management of patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ).
STUDY DESIGN: A prospective study was performed. Positive outcome variables were the resolution of symptoms and the status of the mucosa.
RESULTS: A total of 37 patients are described. The precipitating event was a dental extraction in 22 cases (59.5%). Thirteen patients (35.1%) underwent surgery, and 24 (64.9%) underwent antimicrobial therapy alone. After 2 years, 20 patients (54.1%) presented with soft tissue closure over previously exposed bone, and there were no statistical differences in gender, age, bisphosphonate treatment, or treatment modalities. Spontaneous lesions seemed to have a worse prognosis (P = .001).
CONCLUSIONS: Initial antimicrobial treatment, and later surgery for unresponsive patients, might be a feasible treatment modality for BRONJ. Because these results are not conclusive, it would be very interesting to know if this statement would be the same with a greater number of patients.
STUDY DESIGN: A prospective study was performed. Positive outcome variables were the resolution of symptoms and the status of the mucosa.
RESULTS: A total of 37 patients are described. The precipitating event was a dental extraction in 22 cases (59.5%). Thirteen patients (35.1%) underwent surgery, and 24 (64.9%) underwent antimicrobial therapy alone. After 2 years, 20 patients (54.1%) presented with soft tissue closure over previously exposed bone, and there were no statistical differences in gender, age, bisphosphonate treatment, or treatment modalities. Spontaneous lesions seemed to have a worse prognosis (P = .001).
CONCLUSIONS: Initial antimicrobial treatment, and later surgery for unresponsive patients, might be a feasible treatment modality for BRONJ. Because these results are not conclusive, it would be very interesting to know if this statement would be the same with a greater number of patients.
Предметные рубрики MeSH
AgedAlcohol DrinkingAlendronateAnti-Bacterial AgentsBone Density Conservation AgentsChronic DiseaseClindamycinCohort StudiesCombined Modality TherapyDebridementDiphosphonatesFemaleFollow-Up StudiesFractures, SpontaneousHumansImidazolesJaw DiseasesMaleOral FistulaOsteonecrosisPamidronatePenicillinsProspective StudiesRemission InductionRisk FactorsSmokingTooth ExtractionTreatment OutcomeWound HealingZoledronic Acid