[Symptoms and Signs of Multiple Sclerosis: Beyond Charcot's Triad].

In 1868, Jean-Martin Charcot systematically described the clinical and pathological findings of multiple sclerosis (MS), establishing it as a distinct disease entity. Additionally, he noted the importance of the triad of tremors (intentional tremors), nystagmus, and dysarthria (scanning speech). While he did not propose them as diagnostic criteria, he recognized their value in differentiating MS from other disorders affecting the central nervous system.