MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/ncomms8041

Медицинская библиотека · Nature communications · 2015

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.

Li Changgui, Li Zhiqiang, Liu Shiguo, Wang Can, Han Lin, Cui Lingling, Zhou Jingguo, Zou Hejian, Liu Zhen, Chen Jianhua, Cheng Xiaoyu, Zhou Zhaowei, Ding Chengcheng, Wang Meng, Chen Tong, Cui Ying, He Hongmei, Zhang Keke, Yin Congcong, Wang Yunlong, Xing Shichao, Li Baojie, Ji Jue, Jia Zhaotong, Ma Lidan, Niu Jiapeng, Xin Ying, Liu Tian, Chu Nan, Yu Qing, Ren Wei, Wang Xuefeng, Zhang Aiqing, Sun Yuping, Wang Haili, Lu Jie, Li Yuanyuan, Qing Yufeng, Chen Gang, Wang Yangang, Zhou Li, Niu Haitao, Liang Jun, Dong Qian, Li Xinde, Mi Qing-Sheng, Shi Yongyong

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(-13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(-10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(-8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.

Для цитирования: Li Changgui, Li Zhiqiang, Liu Shiguo, Wang Can, Han Lin, Cui Lingling, Zhou Jingguo, Zou Hejian, Liu Zhen, Chen Jianhua, Cheng Xiaoyu, Zhou Zhaowei, Ding Chengcheng, Wang Meng, Chen Tong, Cui Ying, He Hongmei, Zhang Keke, Yin Congcong, Wang Yunlong, Xing Shichao, Li Baojie, Ji Jue, Jia Zhaotong, Ma Lidan, Niu Jiapeng, Xin Ying, Liu Tian, Chu Nan, Yu Qing, Ren Wei, Wang Xuefeng, Zhang Aiqing, Sun Yuping, Wang Haili, Lu Jie, Li Yuanyuan, Qing Yufeng, Chen Gang, Wang Yangang, Zhou Li, Niu Haitao, Liang Jun, Dong Qian, Li Xinde, Mi Qing-Sheng, Shi Yongyong. Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.. Nature communications. 2015. DOI: 10.1038/ncomms8041.

Предметные рубрики MeSH

Asian PeopleCase-Control StudiesCohort StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGoutHumansMalePolymorphism, Single Nucleotide
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.