Journal of alternative and complementary medicine (New York, N.Y.) · 2009
Resolution of cavitational osteonecrosis through NeuroModulation Technique, a novel form of intention-based therapy: a clinical case study.
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Feinberg Leslie S, Stephan Robert B, Fogarty Kathleen P, Voortman Lynn, Tiller William A, Cassiani-Ingoni Riccardo
Аннотация
OBJECTIVES: This study evaluated the possibility of using NeuroModulation Technique (NMT), a form of intention-based medicine, to induce osteogenesis and healing of cavitational osteonecrosis, a common progressive form of ischemic disease of the alveolar arch.
DESIGN: Eleven (11) adult patients were enrolled based on the presence of lesions in the jawbone. Ten (10) subjects underwent NMT therapy for up to 10 months, while 1 subject received no treatment.
OUTCOME MEASURES: A sensitive analysis of bone density in the alveolar processes of maxilla and mandible was performed before and after therapy using the U.S. Food and Drug Administration-approved Cavitat system of through-transmission ultrasonography and computer imaging.
RESULTS: All subjects presented between one and six cavitational lesions at the first scan, most of which (92%) were associated with sites of previous tooth extraction. NMT-treated patients demonstrated significant improvement in bone density in 27 of the 34 lesions analyzed (79%). The median number of lesions per patient was 4 pretreatment and 0 post-treatment (p < 0.01). One NMT-treated patient, 1 surgically treated patient, and the control subject were also imaged at later time points, showing a durable healing of the lesions through NMT comparable to that of surgery, as opposed to disease persistence in the untreated control.
CONCLUSIONS: NMT therapy provides a safe and potentially effective treatment for jawbone osteonecrosis. Preclinical placebo-controlled trials are encouraged to investigate in depth the potential of NMT for treating inflammatory and degenerative pathologies.
DESIGN: Eleven (11) adult patients were enrolled based on the presence of lesions in the jawbone. Ten (10) subjects underwent NMT therapy for up to 10 months, while 1 subject received no treatment.
OUTCOME MEASURES: A sensitive analysis of bone density in the alveolar processes of maxilla and mandible was performed before and after therapy using the U.S. Food and Drug Administration-approved Cavitat system of through-transmission ultrasonography and computer imaging.
RESULTS: All subjects presented between one and six cavitational lesions at the first scan, most of which (92%) were associated with sites of previous tooth extraction. NMT-treated patients demonstrated significant improvement in bone density in 27 of the 34 lesions analyzed (79%). The median number of lesions per patient was 4 pretreatment and 0 post-treatment (p < 0.01). One NMT-treated patient, 1 surgically treated patient, and the control subject were also imaged at later time points, showing a durable healing of the lesions through NMT comparable to that of surgery, as opposed to disease persistence in the untreated control.
CONCLUSIONS: NMT therapy provides a safe and potentially effective treatment for jawbone osteonecrosis. Preclinical placebo-controlled trials are encouraged to investigate in depth the potential of NMT for treating inflammatory and degenerative pathologies.