Science (New York, N.Y.) · 2007
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chang John T, Palanivel Vikram R, Kinjyo Ichiko, Schambach Felix, Intlekofer Andrew M, Banerjee Arnob, Longworth Sarah A, Vinup Kristine E, Mrass Paul, Oliaro Jane, Killeen Nigel, Orange Jordan S, Russell Sarah M, Weninger Wolfgang, Reiner Steven L
Аннотация
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.
Предметные рубрики MeSH
Adoptive TransferAnimalsAntigen PresentationAntigens, CDCD8 AntigensCD8-Positive T-LymphocytesCell DifferentiationCell DivisionCell LineageCell PolarityDendritic CellsImmunologic MemoryIntracellular Signaling Peptides and ProteinsListeria monocytogenesListeriosisLymphocyte ActivationMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicMitosisNerve Tissue ProteinsProtein Kinase CReceptors, Antigen, T-CellReceptors, InterferonSignal TransductionT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerInterferon gamma ReceptorProtein Kinase C zeta