Neuron · 2024
Non-image-forming photoreceptors improve visual orientation selectivity and image perception.
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Shi Yiming, Zhang Jiaming, Li Xingyi, Han Yuchong, Guan Jiangheng, Li Yilin, Shen Jiawei, Tzvetanov Tzvetomir, Yang Dongyu, Luo Xinyi, Yao Yichuan, Chu Zhikun, Wu Tianyi, Chen Zhiping, Miao Ying, Li Yufei, Wang Qian, Hu Jiaxi, Meng Jianjun, Liao Xiang, Zhou Yifeng, Tao Louis, Ma Yuqian, Chen Jutao, Zhang Mei, Liu Rong, Mi Yuanyuan, Bao Jin, Li Zhong, Chen Xiaowei, Xue Tian
Аннотация
It has long been a decades-old dogma that image perception is mediated solely by rods and cones, while intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible only for non-image-forming vision, such as circadian photoentrainment and pupillary light reflexes. Surprisingly, we discovered that ipRGC activation enhances the orientation selectivity of layer 2/3 neurons in the primary visual cortex (V1) of mice by both increasing preferred-orientation responses and narrowing tuning bandwidth. Mechanistically, we found that the tuning properties of V1 excitatory and inhibitory neurons are differentially influenced by ipRGC activation, leading to a reshaping of the excitatory/inhibitory balance that enhances visual cortical orientation selectivity. Furthermore, light activation of ipRGCs improves behavioral orientation discrimination in mice. Importantly, we found that specific activation of ipRGCs in human participants through visual spectrum manipulation significantly enhances visual orientation discriminability. Our study reveals a visual channel originating from "non-image-forming photoreceptors" that facilitates visual orientation feature perception.