The effect of non-steroidal anti-inflammatory medications on spinal fracture healing: a systematic review.

BACKGROUND

The effect of non-steroidal anti-inflammatory medications (NSAIDs) on fracture healing is a topic of debate. The purpose of this study was to systematically review the effect of NSAID medications on spinal fracture healing rates.

METHODS

We searched the Cochrane Library, PubMed, Medline Ovid, and SCOPUS databases from inception until April 2021, and additionally searched the NIH Clinical Trials Database. Eligible studies included those which reported on spinal fracture healing rates in patients taking NSAIDs. Two reviewers independently assessed all potential studies for eligibility and extracted data. Risk of bias was assessed with validated tools by two reviewers. The primary outcome of interest was healing rates of spinal fractures in patients taking NSAIDs. Secondary outcomes of interest included healing rates stratified by NSAID selectivity.

RESULTS

A total of 1,715 studies were initially screened. After inclusion criteria were applied, three studies (214 patients) were included which discussed spinal fracture healing rates in patients taking NSAIDs. These studies showed acceptable reliability for inclusion. The 3 studies reported heterogeneous results, with one study reporting a 96% healing rate, and another study reporting over 90% non-union rate. The types of fracture, NSAID type, and dosage/duration of NSAID use varied widely amongst studies.

DISCUSSION: This systematic review identified a significant paucity in the literature on the effect of NSAID medications on spinal fracture healing rates. Given the limited number of studies, as well as the heterogeneous results and methods from these studies, no consensus statement can be made on the safety profile of NSAIDs in the context of spinal fractures. Further studies are needed to better address this question.