Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2019
Post-radiosynovectomy imaging utilizing Erbium-169 citrate.
СтатьяНазвание и аннотация: Перевод в очереди
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Farahati Jamshid, Kazek Sandra, Maric Ines, Soestwoehner Thomas, Kalle Patrick, Costa Pedro Fragoso, Jentzen Walter, Stein Linda, Jalilian Amirreza, Kumm Dietmar, Bockisch Andreas, Herrmann Ken
Аннотация
Currently, there is no imaging procedure for radionuclide therapy utilizing Erbium-169 (Er-169). We have recently published the first post-radiosynovectomy imaging of Er-169 citrate in a case report (Farahati et al., 2017). In this study, we performed in-vitro and in-vivo studies to evaluate the feasibility to assess the distribution of Er-169 citrate after radiosynovectomy in fourteen patients with seventeen affected joints treated for refractory chronic synovitis. Post-radiosynovectomy imaging revealed the feasibility of post-radiosynovectomy detection and distribution utilizing Er-169 citrate in all cases. However, additional in-vitro studies including in-vitro imaging, gamma spectrometry and analysis of half-life indicated that emitted gamma-rays of the Ytterbium-169 in the radiopharmaceutical together with bremsstrahlung induced by Er-169 are the imaging source of emitted counts. Post-radiosynovectomy imaging utilizing Er-169 citrate is feasible and should be implemented in the guidelines for theranostics for quality control, patient safety and therapy monitoring.