Topical 5-fluorouracil treatment for psoriatic trachyonychia.

Psoriatic nail involvement is common and usually accompanies other associated cutaneous or systemic lesions. The occurrence of psoriatic nail involvement has been noted in up to 50 percent of patients. There is no consistently effective therapy for psoriatic nail involvement. We report a beneficial response following a short course of topically applied 5 percent 5-fluorouracil cream.