[Follow-up study on cytophagic histiocytic panniculitis with abnormal immunologic findings].

A 41-year-old patient suffering from multiple subcutaneous nodules of 9 years' duration subsequently left a well-demarcated region of atrophy. Histiocytic panniculitis was observed in biopsy specimens with cytophagocytosis. Histiocytosis was found in the bone marrow. These histiocytes were positive for lysozyme and platelets. He later developed fever and hepatomegaly. Laboratory examination revealed leukocytopenia, mild anemia, and liver disfunction as well as abnormal immunologic findings such as positive LE test and ANA, and an increase of serum IgA and complement levels. The patient was successfully treated with systemic administration of prednisolone and azathiopurine++.