Cell reports · 2025
The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses.
СтатьяНазвание и аннотация: Перевод в очереди
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He Chenfei, Wang Shan, Moreews Marion, Pei Shengduo, Chen Guangchun, Li Quan-Zhen, Del Monte Monge Alberto, Ramiro Almudena R, Cai Curtis, Gaya Mauro, Barral Patricia, Buggert Marcus, Batista Facundo D, Karlsson Mikael C I
Аннотация
Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses.