Current opinion in supportive and palliative care · 2010
Bone and paraproteinemias.
Название и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Zangari M, Zhan F, Tricot G
Аннотация
PURPOSE OF REVIEW: Bone has always been considered a target organ for neoplastic disorder. This review analyzed the close interaction between bone microenvironment and paraproteinemias.
RECENT FINDINGS: Paraproteinemias are a group of disorders characterized by the presence of a monoclonal protein measured in the blood or urine. Paraproteinemias include nonmalignant B cell disorders such as monoclonal gammopathy of undetermined significance and malignant diseases as multiple myeloma. All these conditions are characterized by increased risk of osteoporosis/osteopenia, and in the setting of multiple myeloma can manifest with osteolytic pattern.
SUMMARY: This review focuses on the biological aspects of paraproteinemia and bone disease, and indicates possible new therapeutic interventions.
RECENT FINDINGS: Paraproteinemias are a group of disorders characterized by the presence of a monoclonal protein measured in the blood or urine. Paraproteinemias include nonmalignant B cell disorders such as monoclonal gammopathy of undetermined significance and malignant diseases as multiple myeloma. All these conditions are characterized by increased risk of osteoporosis/osteopenia, and in the setting of multiple myeloma can manifest with osteolytic pattern.
SUMMARY: This review focuses on the biological aspects of paraproteinemia and bone disease, and indicates possible new therapeutic interventions.